Title : Circular dichroism spectra and electrophoretic mobility shift assays show that human replication protein A binds and melts intramolecular G-quadruplex structures.

Pub. Date : 2009 Feb 10

PMID : 19187036






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Moreover, hRPA binds to a 26-mer purine-rich quadruplex-forming sequence with an affinity indistinguishable from that for binding to the complementary pyrimidine-rich sequence. pyrimidine replication protein A1 Homo sapiens
2 Thus, DNA secondary structures can significantly modulate the binding affinity of hRPA over and above its known preference for pyrimidine-rich single-stranded sequences, so that at least some intramolecular G-quadruplex structures may not inhibit hRPA binding during DNA replication. pyrimidine replication protein A1 Homo sapiens