Pub. Date : 2010 Jan
PMID : 19184424
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa. | Aspirin | cadherin 1 | Homo sapiens |
| 2 | We investigated the methylation status of CDH1 in noncancerous gastric mucosa in chronic aspirin user, and assessed its effect on methylation-associated carcinogenesis. | Aspirin | cadherin 1 | Homo sapiens |
| 3 | CDH1 methylation more frequently occurred in H. pylori-infection-positive subjects (P < 0.0001), while chronic aspirin users had a significantly lower risk of CDH1 methylation [nonuser versus user 36.1% versus 10.8%; odds ratio (OR) = 0.21, 95% confidence interval (CI) = 0.07-0.63, P = 0.005]. | Aspirin | cadherin 1 | Homo sapiens |
| 4 | Logistic regression analysis showed that chronic aspirin use was the independent factor for lower risk of CDH1 methylation (adjusted OR = 0.21, 95%CI = 0.07-0.66, P = 0.008). | Aspirin | cadherin 1 | Homo sapiens |
| 5 | Chronic aspirin use was associated with lower risk of CDH1 methylation in H. pylori-positive subjects (nonuser versus user 49.5% versus 19.0%; OR = 0.24, 95%CI = 0.08-0.76, P = 0.01). | Aspirin | cadherin 1 | Homo sapiens |
| 6 | Our data suggest that chronic aspirin use is associated with reduced risk of CDH1 methylation in human gastric mucosa. | Aspirin | cadherin 1 | Homo sapiens |