Title : Transferrin receptor-targeted lipid nanoparticles for delivery of an antisense oligodeoxyribonucleotide against Bcl-2.

Pub. Date : 2009 Jan-Feb

PMID : 19183107






1 Functional Relationships(s)
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1 Furthermore, up-regulation of TfR expression in leukemia cells by iron chelator deferoxamine resulted in a further increase in antisense effect (up to 79% Bcl-2 reduction in K562 at the mRNA level) and in caspase-dependent apoptosis (by approximately 3-fold) by Tf-LN. Deferoxamine BCL2 apoptosis regulator Homo sapiens