Pub. Date : 2009 Jun
PMID : 19181503
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Herein, we investigated the effect of silibinin, a major constituent (flavanolignan) of the fruits of Silybum marianum, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and VEGF expression in MCF-7 human breast cancer cells. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 2 | The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 3 | The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 4 | To investigate the regulatory mechanism of silibinin on TPA-induced MMP-9 and VEGF expression, we pretreated cells with various inhibitors, such as UO126 (MEK1/2 inhibitor), SP600125 (JNK inhibitor), and SB203580 (p38 inhibitor). | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 5 | TPA-induced VEGF expression was also suppressed by UO126. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |
| 6 | Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells. | Tetradecanoylphorbol Acetate | vascular endothelial growth factor A | Homo sapiens |