Title : Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.

Pub. Date : 2009 Apr 1

PMID : 19176602






2 Functional Relationships(s)
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Protein Name
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1 Activity of NOS3 was characterized by conversion of arginine to citrulline, BH(4) intracellular availability, cGMP, and superoxide anion production. Superoxides nitric oxide synthase 3 Homo sapiens
2 In aged cells with an uncoupled NOS3 as shown by the reduced BH(4) level, the increase in superoxide anion and the lower production of cGMP and the decrease in NO bioavailability were linearly correlated with the increase in basal [Ca(2+)](i). Superoxides nitric oxide synthase 3 Homo sapiens