Title : Cyclic AMP signaling as a mediator of vasculogenic mimicry in aggressive human melanoma cells in vitro.

Pub. Date : 2009 Feb 1

PMID : 19176384






2 Functional Relationships(s)
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Protein Name
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1 Phosphorylation of ERK1/2 was PKA-independently inhibited by forskolin but not inhibited by Epac/Rap1 signaling, PKA modulation, or GPCR ligands. Colforsin mitogen-activated protein kinase 3 Homo sapiens
2 Collectively, these data show that forskolin strongly inhibits VM through PKA-independent activation of Epac/Rap1, PKA-, and Epac-independent inactivation of ERK1/2 and inhibition of PI3K/Akt. Colforsin mitogen-activated protein kinase 3 Homo sapiens