Title : Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

Pub. Date : 2009 Feb 17

PMID : 19170619






1 Functional Relationships(s)
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1 This CA IX mimic has been characterized kinetically using (18)O-exchange and structurally using X-ray crystallography, alone and in complex with five CA sulfonamide-based inhibitors (acetazolamide, benzolamide, chlorzolamide, ethoxzolamide, and methazolamide), and compared to CA II. Acetazolamide carbonic anhydrase 9 Homo sapiens