Title : Testosterone alleviates tumor necrosis factor-alpha-mediated tissue factor pathway inhibitor downregulation via suppression of nuclear factor-kappa B in endothelial cells.

Pub. Date : 2009 Mar

PMID : 19169266






5 Functional Relationships(s)
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1 Testosterone alleviates tumor necrosis factor-alpha-mediated tissue factor pathway inhibitor downregulation via suppression of nuclear factor-kappa B in endothelial cells. Testosterone nuclear factor kappa B subunit 1 Homo sapiens
2 To study the cellular mechanism of testosterone"s action, nuclear factor-kappa B (NF-kappaB) translocation was confirmed by electrophoretic mobility shift assays. Testosterone nuclear factor kappa B subunit 1 Homo sapiens
3 To study the cellular mechanism of testosterone"s action, nuclear factor-kappa B (NF-kappaB) translocation was confirmed by electrophoretic mobility shift assays. Testosterone nuclear factor kappa B subunit 1 Homo sapiens
4 NF-kappaB DNA-binding activity was significantly suppressed by testosterone (P < 0.05). Testosterone nuclear factor kappa B subunit 1 Homo sapiens
5 This suggests that physiological testosterone concentrations may exert their antithrombotic effects on TFPI expression during inflammation by downregulating NF-kappaB activity. Testosterone nuclear factor kappa B subunit 1 Homo sapiens