Title : p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes.

Pub. Date : 2009 Mar 13

PMID : 19168439






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 p66Shc links alpha(1)-ARs to an AKT signaling pathway that selectively phosphorylates/inactivates FOXO transcription factors and downregulates the ROS-scavenging protein manganese superoxide dismutase (MnSOD); the alpha(1)-AR-p66Shc-dependent pathway involving AKT does not regulate GSK3. Reactive Oxygen Species superoxide dismutase 2 Homo sapiens