Title : Extracellular ATP, intracellular calcium and canalicular contraction in rat hepatocyte doublets.

Pub. Date : 1991 Oct

PMID : 1916664






1 Functional Relationships(s)
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1 Cytochalasin D, which depolymerizes actin filaments, inhibited ATP-induced canalicular contraction, but not the increase in [Ca2+]i. Microdialysis of myosin light chain kinase and its Ca(2+)-independent fragment (but not the heat-denatured fragment, albumin, trypsin plus soybean inhibitor or buffer) into one hepatocyte of a doublet resulted in canalicular contraction in 86% of doublets. Cytochalasin D myosin light chain kinase Rattus norvegicus