Title : Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro.

Pub. Date : 2009 Feb

PMID : 19159406






1 Functional Relationships(s)
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1 Electrophysiological testing revealed low-affinity inhibition of the potassium current through hERG channels expressed in HEK293 cells (IC(50) = 171 microM oxycodone). Potassium ETS transcription factor ERG Homo sapiens