Title : Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes.

Pub. Date : 1991 Nov

PMID : 1915667






2 Functional Relationships(s)
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1 In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 In this paper we show that epidermal growth factor (EGF)- and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced expression of the c-fos and c-jun protooncogenes is decreased in microgravity, while no effect of gravity changes was observed on A23187- and forskolin-induced expression of these genes. Tetradecanoylphorbol Acetate Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens