Title : Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo.

Pub. Date : 2009 Jan

PMID : 19152549






3 Functional Relationships(s)
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1 We compared the effects of acetylsalicylic acid, ibuprofen, nabumetone and nimesulide on COX-1 and COX-2 pathways in healthy volunteers in an ex vivo set-up using single oral doses commonly used to treat acute pain. nimesulide prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Nimesulide caused almost complete suppression of COX-2 activity and a partial reduction of COX-1 activity. nimesulide prostaglandin-endoperoxide synthase 2 Homo sapiens
3 This confirms the relative COX-2 selectivity of nimesulide. nimesulide prostaglandin-endoperoxide synthase 2 Homo sapiens