Title : Chlorophyllin significantly reduces benzo[a]pyrene-DNA adduct formation and alters cytochrome P450 1A1 and 1B1 expression and EROD activity in normal human mammary epithelial cells.

Pub. Date : 2009 Mar

PMID : 19152381






2 Functional Relationships(s)
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1 Using reverse transcription real time PCR (RT-PCR) the maximal inhibition of BP-induced gene expression, >85% for CYP1A1 and >70% for CYP1B1, was observed in the preCHLN, postBP+CHLN group. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 Therefore, the addition of CHLN to BP-exposed cells reduced BPdG formation and CYP1A1 and CYP1B1 expression, but EROD activity was not significantly reduced. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens