Title : Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemotherapy in locally advanced breast cancer with Her2/neu expression.

Pub. Date : 2008 Oct

PMID : 19151448






2 Functional Relationships(s)
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1 RESULTS: the polymorphism of MDR1 gene at cDNA position 3435 located in exon 26 has been shown to be correlated with clinical response to Anthracycline chemotherapy in breast cancer patients, without being affected by the positive or negative Her-2 expression. Anthracyclines ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSION: breast cancer patients with positive Her-2 expression do not always respond to Anthracycline, it means that only patients with T/T genotype at position 3435 located in exon 26 of MDR1 gene have clinical response, while patients have C/T genotype do not show clinical response. Anthracyclines ATP binding cassette subfamily B member 1 Homo sapiens