Title : The possible use of oximes as antidotal therapy in organophosphate-induced brain damage.

Pub. Date : 2009 Mar

PMID : 19150463






3 Functional Relationships(s)
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1 This implies that the main beneficial effect of oximes may result from reactivation of AChE activity in respiratory muscles rather than in the brain. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Albeit the concentration of oximes in the central nervous system is significantly lower than in the plasma, they do gain access into the brain and are able to reactivate inhibited local AChE. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens
3 In this review, we focus on the ability of oximes to act in the brain and protect the central nervous system from OP-induced injury, either by direct reactivation of AChE or by other pharmacological mechanisms. Oximes acetylcholinesterase (Cartwright blood group) Homo sapiens