Title : Role of individual domains and identification of internal gap in human guanylate binding protein-1.

Pub. Date : 2009 Feb 27

PMID : 19150356






2 Functional Relationships(s)
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1 Our data also show that the N-terminal globular domain is able to perform only the first catalysis (GTP to GDP, an activity associated with basal level), but the helical domain in the full-length protein stimulates the hydrolysis of GTP to GMP with higher GMP formation by preventing the dissociation of GDP-bound enzyme dimer. Guanosine Triphosphate 5'-nucleotidase, cytosolic II Homo sapiens
2 Our data also show that the N-terminal globular domain is able to perform only the first catalysis (GTP to GDP, an activity associated with basal level), but the helical domain in the full-length protein stimulates the hydrolysis of GTP to GMP with higher GMP formation by preventing the dissociation of GDP-bound enzyme dimer. Guanosine Triphosphate 5'-nucleotidase, cytosolic II Homo sapiens