Title : HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.

Pub. Date : 2009 Mar 1

PMID : 19150257






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Consistently, HCT116p53(-/-) cells are more resistant to imatinib than parental cells, suggesting that imatinib activity is partly dependent on p53 in colon cancer cells. Imatinib Mesylate tumor protein p53 Homo sapiens
2 Consistently, HCT116p53(-/-) cells are more resistant to imatinib than parental cells, suggesting that imatinib activity is partly dependent on p53 in colon cancer cells. Imatinib Mesylate tumor protein p53 Homo sapiens