Pub. Date : 2009 Mar
PMID : 19147120
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine stimulates the expression of cyclooxygenase-2 mRNA via NFkappaB activation in human gingival fibroblasts. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | We investigated the involvement of the transcription nuclear factor kappa B (NFkappaB) in the nicotine-induced expression of cyclooxygenase-2 (COX-2), a key enzyme for prostaglandin synthesis, in human gingival fibroblasts. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA in a time- and dose-dependent manner. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | The nicotine-stimulated release of prostaglandin E(2) and expression of COX-2 mRNA and protein were inhibited by an NFkappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), by approximately 50%. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | These results suggest that nicotine is taken up by human gingival fibroblasts and that it then stimulates COX-2 expression via the activation of NFkappaB and the subsequent release of prostaglandin E(2). | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |