Pub. Date : 2009 Apr 1
PMID : 19130504
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | HIV-1 Nef induces p47(phox) phosphorylation leading to a rapid superoxide anion release from the U937 human monoblastic cell line. | Superoxides | S100 calcium binding protein B | Homo sapiens |
| 2 | We have recently shown that the inducible expression of HIV-1 Nef in human macrophages cell line modulates in bi-phasic mode the superoxide anion release by NADPH oxidase, inducing a fast increase of the superoxide production, followed by a delayed strong inhibition mediated by Nef-induced soluble factor(s). | Superoxides | S100 calcium binding protein B | Homo sapiens |
| 3 | We have recently shown that the inducible expression of HIV-1 Nef in human macrophages cell line modulates in bi-phasic mode the superoxide anion release by NADPH oxidase, inducing a fast increase of the superoxide production, followed by a delayed strong inhibition mediated by Nef-induced soluble factor(s). | Superoxides | S100 calcium binding protein B | Homo sapiens |
| 4 | Our study is focused on the molecular mechanisms involved in Nef-mediated activation of NADPH oxidase and superoxide anion release. | Superoxides | S100 calcium binding protein B | Homo sapiens |
| 5 | Using U937 cells stably transfected with different Nef alleles, we found that both Nef membrane localization and intact SH3-binding domain are needed to induce superoxide release. | Superoxides | S100 calcium binding protein B | Homo sapiens |
| 6 | Using U937 cells stably transfected with different Nef alleles, we found that both Nef membrane localization and intact SH3-binding domain are needed to induce superoxide release. | Superoxides | S100 calcium binding protein B | Homo sapiens |
| 7 | The lack of effect during treatment with a specific MAPK pathway inhibitor, PD98059, demonstrated that Nef-induced superoxide release is independent of Erk1/2 phosphorylation. | Superoxides | S100 calcium binding protein B | Homo sapiens |