Pub. Date : 2009 Jan 13
PMID : 19124772
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alkylation-induced O(6)-methylguanine (O(6)MeG) DNA lesions can be mutagenic or cytotoxic if unrepaired by the O(6)MeG-DNA methyltransferase (Mgmt) protein. | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Mus musculus |
| 2 | Alkylation-induced O(6)-methylguanine (O(6)MeG) DNA lesions can be mutagenic or cytotoxic if unrepaired by the O(6)MeG-DNA methyltransferase (Mgmt) protein. | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Mus musculus |
| 3 | Rapidly proliferating tissues in Mgmt-null mice (bone marrow, thymus, and spleen) are extremely sensitive to apoptosis induced by O(6)MeG-producing agents. | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Mus musculus |