Title : MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents.

Pub. Date : 2009 Jun

PMID : 19123050






2 Functional Relationships(s)
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1 However, MDR1 (1199A) cells displayed greater resistance to vinblastine, vincristine, paclitaxel, and VP-16 (11-, 2.9-, 1.9-, and 2.9-fold, respectively). Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens
2 Efflux of doxorubicin was similar between MDR1 wt - and MDR1 (1199A)-expressing cells, while P-gp-mediated transport was greater for vinblastine and vincristine in MDR1 (1199A) cells (2.9- and 2.0-fold, respectively). Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens