Title : Long-term ethanol exposure impairs neuronal differentiation of human neuroblastoma cells involving neurotrophin-mediated intracellular signaling and in particular protein kinase C.

Pub. Date : 2009 Mar

PMID : 19120063






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 BDNF-mediated activation of the ERK cascade was found to be continuously impaired by ethanol. Ethanol mitogen-activated protein kinase 1 Homo sapiens
2 RKIP, acting as a signaling switch at the merge of the PKC cascade and the Raf/MEK/ERK cascade, was associated with neuronal differentiation and significantly reduced in ethanol treatment. Ethanol mitogen-activated protein kinase 1 Homo sapiens
3 Thus, reduced RKIP and PKC levels and subsequently reduced positive feedback on ERK activation provide an explanation for the striking effects of long-term ethanol exposure on BDNF signal transduction and neuronal differentiation, respectively. Ethanol mitogen-activated protein kinase 1 Homo sapiens