Title : Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells.

Pub. Date : 2009 Mar

PMID : 19112101






2 Functional Relationships(s)
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1 Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold) and attenuated LPA-induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
2 These results suggest that native AGK regulates LPA-mediated IL-8 secretion involving MAPKs, NF-kappaB, and transactivation of EGF-R. lysophosphatidic acid epidermal growth factor receptor Homo sapiens