Title : Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs.

Pub. Date : 2009 Jan

PMID : 19110207






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1 This review discusses the multimodal effects of two rasagiline-containing hybrid molecules, namely ladostigil and M-30, concerning their neuroprotective molecular mechanisms in vivo and in vitro, including regulation of amyloid precursor protein processing, activation of protein kinase C, and mitogen-activated protein kinase signaling pathways, inhibition of cell death markers and upregulation of neurotrophic factors. rasagiline amyloid beta precursor protein Homo sapiens