Title : Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for non-steroidal anti-inflammatory drug (NSAID)-dependent exacerbation of colitis.

Pub. Date : 2009 Jan 28

PMID : 19101538






2 Functional Relationships(s)
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1 The intestinal level of PGE(2) dramatically decreased in response to administration of COX-1- and COX-2-selective inhibitors, and exogenously administered PGE(2) suppressed the exacerbation of colitis by NSAIDs. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 This study provides evidence that inhibition of both COX-1 and COX-2 and the resulting dramatic decrease in the intestinal level of PGE(2) is responsible for NSAID-dependent exacerbation of DSS-induced colitis. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens