Title : Preneoplastic transformation in mouse mammary tissue: identification and validation of intermediate biomarkers for chemoprevention.

Pub. Date : 1991 May-Jun

PMID : 1909512






1 Functional Relationships(s)
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1 DMBA treatment induced binding of ras oncogene product ras p21 to [alpha 32P] GTP, altered estradiol metabolism by increasing the ratio of C16 alpha/C2 hydroxylation in favor of 16 alpha-OHE1 formation, and exhibited high frequency of MAL. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene cyclin-dependent kinase inhibitor 1A (P21) Mus musculus