Pub. Date : 1991 Sep 5
PMID : 1909330
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 2 | 264, 4583-4589), have reduced ability to release arachidonic acid (20:4) from membrane phospholipids in response to either TNF or the calcium ionophore A23187 treatment. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 3 | Therefore, the release of arachidonic acid from phospholipids appears to be a critical element in the signaling pathway utilized by TNF and is essential to the rapid cytotoxic response elicited by TNF in the absence of protein synthesis in wild-type TA1 cells. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |
| 4 | Therefore, the release of arachidonic acid from phospholipids appears to be a critical element in the signaling pathway utilized by TNF and is essential to the rapid cytotoxic response elicited by TNF in the absence of protein synthesis in wild-type TA1 cells. | Arachidonic Acid | tumor necrosis factor | Homo sapiens |