Title : Signaling threshold regulation by the Ras effector IMP.

Pub. Date : 2009 Apr 24

PMID : 19091743






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 IMP concentrations are directly regulated by Ras, through induction of autoubiquitination, to permit productive Raf-MEK complex assembly. Inosine Monophosphate mitogen-activated protein kinase kinase 7 Homo sapiens
2 Inhibition of Raf-MEK pathway activation by IMP occurs through the inactivation of KSR, a scaffold/adapter protein that couples activated Raf to its substrate MEK1. Inosine Monophosphate mitogen-activated protein kinase kinase 7 Homo sapiens