Title : Pathology is alleviated by doxycycline in a laminin-alpha2-null model of congenital muscular dystrophy.

Pub. Date : 2009 Jan

PMID : 19086074






1 Functional Relationships(s)
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1 To identify a possible pharmacological therapy for laminin-alpha2 deficiency, we designed this study to determine whether treatment with minocycline or doxycycline, which are tetracycline derivatives reported to have antiapoptotic effects in mammals, would significantly increase lifespan and improve neuromuscular function in laminin-alpha2-deficient mice. Tetracycline laminin, alpha 2 Mus musculus