Pub. Date : 2009 Mar
PMID : 19086036
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis. | Lithocholic Acid | cyclin D1 | Homo sapiens |
| 2 | Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis. | Lithocholic Acid | cyclin D1 | Homo sapiens |
| 3 | Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis. | Lithocholic Acid | cyclin D1 | Homo sapiens |
| 4 | Lithocholic acid (LCA) treatment of primary human hepatocytes and HuH-7 cells induced a similar switch from Mnt to Myc and increased p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis. | Lithocholic Acid | cyclin D1 | Homo sapiens |
| 5 | Blocking c-Myc induction in HuH-7 cells prevented the LCA-mediated increase in p53 and cyclin D1 expression and reduced apoptosis. | Lithocholic Acid | cyclin D1 | Homo sapiens |
| 6 | Lowering Mnt expression further enhanced LCA"s inductive effect on p53 and cyclin D1. | Lithocholic Acid | cyclin D1 | Homo sapiens |
| 7 | CONCLUSION: The switch from Mnt to Myc during bile duct ligation and in hepatocytes treated with LCA is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis. | Lithocholic Acid | cyclin D1 | Homo sapiens |