Title : ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.

Pub. Date : 2009 May

PMID : 19085995






1 Functional Relationships(s)
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1 RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta. tempol heat shock protein family B (small) member 1 Homo sapiens