Pub. Date : 2009 Mar
PMID : 19084066
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Genetic reduction or elimination of CHIP accelerates disease in transgenic mice expressing polyQ-expanded ataxin-3, the disease protein in Spinocerebellar Ataxia Type 3 (SCA3). | polyglutamine | ataxin 3 | Mus musculus |
2 | Genetic reduction or elimination of CHIP accelerates disease in transgenic mice expressing polyQ-expanded ataxin-3, the disease protein in Spinocerebellar Ataxia Type 3 (SCA3). | polyglutamine | ataxin 3 | Mus musculus |
3 | Genetic reduction or elimination of CHIP accelerates disease in transgenic mice expressing polyQ-expanded ataxin-3, the disease protein in Spinocerebellar Ataxia Type 3 (SCA3). | polyglutamine | ataxin 3 | Mus musculus |
4 | Our results support an aggregation model of polyQ disease pathogenesis in which ataxin-3 microaggregates are a neurotoxic species, and suggest that enhancing CHIP activity is a possible route to therapy for SCA3 and other polyQ diseases. | polyglutamine | ataxin 3 | Mus musculus |