Title : Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction.

Pub. Date : 2008 Dec

PMID : 19076449






3 Functional Relationships(s)
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1 To examine whether NAD(+) mediates neuroprotective effects, nicotinamide, a precursor of NAD(+) and inhibitor of SIRT1 and poly (ADP-ribose) polymerase 1 (PARP1) (two NAD(+)-dependent enzymes), was employed. Niacinamide poly (ADP-ribose) polymerase family, member 1 Mus musculus
2 To examine whether NAD(+) mediates neuroprotective effects, nicotinamide, a precursor of NAD(+) and inhibitor of SIRT1 and poly (ADP-ribose) polymerase 1 (PARP1) (two NAD(+)-dependent enzymes), was employed. Niacinamide poly (ADP-ribose) polymerase family, member 1 Mus musculus
3 Nicotinamide attenuated excitotoxic death and preserved cellular NAD(+) levels to support SIRT1 and PARP 1 activities. Niacinamide poly (ADP-ribose) polymerase family, member 1 Mus musculus