Title : Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules.

Pub. Date : 2009 Apr

PMID : 19074508






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 When compared to the isolated MT binding repeats (K(d)=0.3 microM), the phospho-Tau retains a substantial affinity for preformed MTs (K(d)=11 nM), suggesting that the phosphorylated proline-rich region still participates in the binding event. Proline microtubule associated protein tau Homo sapiens