Title : Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Pub. Date : 2009 Feb 6

PMID : 19074428






1 Functional Relationships(s)
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1 We demonstrate that BACE1 undergoes S-palmitoylation at four Cys residues at the junction of transmembrane and cytosolic domains, and Ala substitution at these four residues is sufficient to displace BACE1 from lipid rafts. Cysteine beta-secretase 1 Homo sapiens