Title : The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis.

Pub. Date : 2009 Feb 6

PMID : 19068483






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PI3K/Akt regulated early steps of de novo synthesis by modulating phosphoribosylpyrophosphate production by the non-oxidative pentose phosphate pathway and late steps by modulating activity of the bifunctional enzyme aminoimidazole-carboxamide ribonucleotide transformylase IMP cyclohydrolase, an enzyme not previously known to be regulated. Pentosephosphates thymoma viral proto-oncogene 1 Mus musculus