Title : Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment.

Pub. Date : 2009 Jan

PMID : 19067746






2 Functional Relationships(s)
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1 In this study, the effect of different treatment regimens for MM on serum DKK-1 was evaluated and correlated with the response to treatment in 101 myeloma patients receiving bortezomib, thalidomide, lenalidomide, adriamycin and dexamethasone (AD) or high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (ASCT). Lenalidomide dickkopf WNT signaling pathway inhibitor 1 Homo sapiens
2 A significant decrease of DKK-1 after therapy was seen in the following groups: Bortezomib (4059 pg/mL vs. 1862 pg/mL, P = 0.016), lenalidomide (11837 pg/mL vs. 4374 pg/mL, P = 0.039), AD (1668 pg/mL vs. 1241 pg/mL, P = 0.016), and AD + HDCT + ASCT (2446 pg/mL vs. 1082 pg/mL, P = 0.001). Lenalidomide dickkopf WNT signaling pathway inhibitor 1 Homo sapiens