Pub. Date : 2009 Mar
PMID : 19067706
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. | Bexarotene | tumor protein p53 | Homo sapiens |
| 2 | We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2. | Bexarotene | tumor protein p53 | Homo sapiens |
| 3 | We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2. | Bexarotene | tumor protein p53 | Homo sapiens |
| 4 | We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2. | Bexarotene | tumor protein p53 | Homo sapiens |
| 5 | Bexarotene-mediated ataxia telangiectasia mutated protein (ATM) activation in all studied lines suggests that ATM is likely to be the p53/p73 upstream activator. | Bexarotene | tumor protein p53 | Homo sapiens |
| 6 | CONCLUSIONS: Our data indicate for the first time that bexarotene exerts its effect in CTCL mainly by triggering the p53/p73-dependent cell cycle inhibition pathway, probably by upstream ATM activation. | Bexarotene | tumor protein p53 | Homo sapiens |