Pub. Date : 2009 Mar
PMID : 19067706
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bexarotene upregulated and activated Bax in sensitive lines, although not enough to signal significant apoptosis. | Bexarotene | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | We further found that bexarotene activates p53 by phosphorylation at Ser15, which influences the binding of p53 to promoters for cell cycle arrest, induces p73 upregulation, and, in concordance, also modulates some p53/p73 downstream target genes, such as p21, Bax, survivin and cdc2. | Bexarotene | BCL2 associated X, apoptosis regulator | Homo sapiens |