Pub. Date : 2009 Jan 5
PMID : 19059405
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SP600125 negatively regulates the mammalian target of rapamycin via ATF4-induced Redd1 expression. | pyrazolanthrone | activating transcription factor 4 | Homo sapiens |
| 2 | Overexpression of ATF4 upregulated the expression of Redd1, while suppression of ATF4 expression by siRNA enhanced the level of S6 phosphorylation by downregulating the SP600125-induced increase in Redd1 expression. | pyrazolanthrone | activating transcription factor 4 | Homo sapiens |
| 3 | Overexpression of ATF4 upregulated the expression of Redd1, while suppression of ATF4 expression by siRNA enhanced the level of S6 phosphorylation by downregulating the SP600125-induced increase in Redd1 expression. | pyrazolanthrone | activating transcription factor 4 | Homo sapiens |
| 4 | Together, these results indicate that SP600125 inhibits mTOR activity via an ATF4-induced increase in Redd1 expression. | pyrazolanthrone | activating transcription factor 4 | Homo sapiens |