Title : The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: role of intramolecular electron transfer mechanism?

Pub. Date : 2009 Apr 15

PMID : 19056332






2 Functional Relationships(s)
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1 Here we investigated the effects of methionine on tyrosyl nitration and oxidation induced by myeloperoxidase (MPO), H2O2 and NO2(-) and peroxynitrite (ONOO(-)) or ONOO(-) and bicarbonate (HCO3(-)) in model peptides, tyrosylmethionine (YM), tyrosylphenylalanine (YF) and tyrosine. Methionine myeloperoxidase Homo sapiens
2 Here we investigated the effects of methionine on tyrosyl nitration and oxidation induced by myeloperoxidase (MPO), H2O2 and NO2(-) and peroxynitrite (ONOO(-)) or ONOO(-) and bicarbonate (HCO3(-)) in model peptides, tyrosylmethionine (YM), tyrosylphenylalanine (YF) and tyrosine. Methionine myeloperoxidase Homo sapiens