Title : Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.

Pub. Date : 1991 Jun

PMID : 1903680






2 Functional Relationships(s)
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1 Experiments were designed to examine the effect of hirudin (which inactivates thrombin) and the nitrovasodilators nitroglycerin and 3-morpholinosydnonimine on the spontaneous and thrombin-stimulated release of endothelin in intact blood vessels. linsidomine coagulation factor II, thrombin Homo sapiens
2 The inhibitory effects of both 3-morpholinosydnonimine and nitroglycerin on the thrombin-stimulated release of endothelin were abolished in the presence of an inhibitor of soluble guanylate cyclase, methylene blue (10(-5) M). linsidomine coagulation factor II, thrombin Homo sapiens