Title : Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions.

Pub. Date : 1977 Mar

PMID : 190267






2 Functional Relationships(s)
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1 Incubation of platelets with either dibutyryl cyclic adenosine 3",5"-monophosphate (dBcAMP) or prostaglandin E1 (PGE1) before thrombin addition blocks the subsequent formation of oxygenated products of arachidonic acid including thromboxane A2, thromboxane B2, and malonaldehyde. Bucladesine coagulation factor II, thrombin Homo sapiens
2 Prior treatment of platelets with dBcAMP or PGE1 reverses the thrombin inhibition of the acetylation of cyclo-oxygenase. Bucladesine coagulation factor II, thrombin Homo sapiens