Title : Efficacy of simvastatin treatment of valvular interstitial cells varies with the extracellular environment.

Pub. Date : 2009 Feb

PMID : 19023089






2 Functional Relationships(s)
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1 Transforming growth factor (TGF)-beta1 was also applied as a disease stimulus to VICs on 2-D surfaces or encapsulated in 3-D collagen gels and combined with different temporal applications of simvastatin. Simvastatin transforming growth factor beta 1 Homo sapiens
2 These effects were mimicked in 3-D cultures, wherein simvastatin reversed TGF-beta1-induced contraction. Simvastatin transforming growth factor beta 1 Homo sapiens