Pub. Date : 2009 Feb
PMID : 19022936
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 2 | The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1). | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 3 | The conversion of oseltamivir to its active metabolite oseltamivir carboxylate is dependent on ester hydrolysis mediated by carboxylesterase 1 (CES1). | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 4 | The aim of the present study was to investigate the function of these mutations on activating (hydrolyzing) oseltamivir to oseltamivir carboxylate using the cell lines expressing wild type (WT) and each mutant CES1. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 5 | In vitro incubation studies demonstrated that the S9 fractions prepared from the cells transfected with WT CES1 and human liver tissues rapidly convert oseltamivir to oseltamivir carboxylate. | Oseltamivir | carboxylesterase 1 | Homo sapiens |
| 6 | These results suggest that the therapeutic efficacy of oseltamivir could be compromised in treated patients expressing either functional CES1 mutation. | Oseltamivir | carboxylesterase 1 | Homo sapiens |