Title : TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.

Pub. Date : 2008 Dec

PMID : 19020730






2 Functional Relationships(s)
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1 TAE226 inhibited the expression of mTOR, Akt, p70S6K and S6 as well as the phosphorylation of mTOR (Ser2448), Akt (Ser473), p70S6K (Thr389) and S6 (Ser240/244). TAE226 AKT serine/threonine kinase 1 Homo sapiens
2 TAE226 inhibited the expression of mTOR, Akt, p70S6K and S6 as well as the phosphorylation of mTOR (Ser2448), Akt (Ser473), p70S6K (Thr389) and S6 (Ser240/244). TAE226 AKT serine/threonine kinase 1 Homo sapiens