Pub. Date : 2008 Dec
PMID : 19020709
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. | pregna-4,17-diene-3,16-dione | vascular endothelial growth factor A | Homo sapiens |
| 2 | Using chromatin immunoprecipitation assay, we tested whether guggulsterone affects the recruitment of STAT3, ARNT and HIF-1alpha to the human VEGF promoter. | pregna-4,17-diene-3,16-dione | vascular endothelial growth factor A | Homo sapiens |
| 3 | Guggulsterone significantly reduced cell viability in colon cancer cells in a dose-dependent manner and blocked VEGF, ARNT and STAT3 expression prominently in hypoxic conditions. | pregna-4,17-diene-3,16-dione | vascular endothelial growth factor A | Homo sapiens |
| 4 | The recruitment of STAT3 and ARNT, but not HIF-1alpha, to the VEGF promoter was inhibited by guggulsterone treatment. | pregna-4,17-diene-3,16-dione | vascular endothelial growth factor A | Homo sapiens |
| 5 | The results of this study suggest that guggulsterone not only induces apoptosis, but also inhibits angiogenesis and metastasis in colon cancer cells by blocking STAT3 and VEGF expression, suggesting its therapeutic potential in the treatment of colorectal cancer. | pregna-4,17-diene-3,16-dione | vascular endothelial growth factor A | Homo sapiens |