Pub. Date : 1991 May 1
PMID : 1901891
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | administration of IFN-gamma (10,000 U/mouse) strongly induced expression of IP-10 mRNA in the adherent cell population of the spleen, thioglycollate-elicited peritoneal macrophages were essentially unresponsive at the same dose. | Thioglycolates | interferon gamma | Mus musculus |
| 2 | This differential expression of IP-10 was a consequence of different concentration requirements for IFN-gamma in the two cell types; thioglycollate-elicited macrophages required five- to 10-fold more IFN-gamma than did resident cells to achieve comparable IP-10 mRNA levels whether the agent was provided in vitro or in vivo. | Thioglycolates | interferon gamma | Mus musculus |
| 3 | This differential expression of IP-10 was a consequence of different concentration requirements for IFN-gamma in the two cell types; thioglycollate-elicited macrophages required five- to 10-fold more IFN-gamma than did resident cells to achieve comparable IP-10 mRNA levels whether the agent was provided in vitro or in vivo. | Thioglycolates | interferon gamma | Mus musculus |