Title : Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.

Pub. Date : 2009 Feb

PMID : 19010934






1 Functional Relationships(s)
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1 Here, we show that three enzymes belonging to the 1B group of the aldo-keto reductase (AKR) superfamily, i.e., human placental aldose reductase (AKR1B1), mouse kidney aldose reductase (AKR1B3) and mouse vas deferens protein (AKR1B7), catalyse the reduction of prostaglandin (PG) H(2), a common intermediate of various prostanoids, to form PGF(2alpha) in the presence of NADPH. NADP aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus